Review Article necessary and various intracanal medicaments have been tried. Intracanal medicaments, calcium hydroxide, antibiotics, corticosteroids. free root canal systems, especially in pulpless teeth, it is necessary to use intra- canal medicaments. These medicaments must be capable of destroying bacteria . Request PDF on ResearchGate | Antibiotics as intracanal medicaments: a review | Antibiotics are an extremely valuable addition to the armamentarium.

Author: Yolkis Gakazahn
Country: Iceland
Language: English (Spanish)
Genre: Software
Published (Last): 10 September 2016
Pages: 346
PDF File Size: 6.60 Mb
ePub File Size: 18.62 Mb
ISBN: 556-2-93350-911-6
Downloads: 33140
Price: Free* [*Free Regsitration Required]
Uploader: Tum

NaOCl was generally the most effective agent followed by iodine.

Antibiotics as intracanal medicaments: a review.

Torabinejad M, Bahjri K. Effectiveness of electrochemically activated water as an irrigant in an infected tooth model. Interestingly, a recently published study contemplating the clinical aspects about the bacterial biofilm is the only one medicamente high level of evidence. This work was developed based on an analysis of longitudinal studies from a quantitative systematic review of results of several investigations.

Biofilm formation of oral and endodontic Enterococcus faecalis.

Bacterial biofilms in nature and disease. A major advantage is the protection that the biofilm provides to colonizing species from microorganisms competing for environmental factors, such as host defense mechanisms, and from potentially toxic substances in the environment, such as lethal chemicals or antibiotics.

Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection. Biofilms can also facilitate processing and uptake of nutrients, cross-feeding one species providing nutrients to anotherremoval of potentially harmful metabolic products often used by other bacteria as well as the development of an appropriate physicochemical environment such as a properly lowering the oxidation reduction potential.

Photophysical, photochemical, and photobiological characterization of methylene blue formulations for light-activated root canal disinfection. Socransky and Haffajee 37 reported that the reason for the existence of a biofilm is that it allows microorganisms to stick to and multiply on surfaces. The antimicrobial efficacy of intracanal medicaments on bacterial biofilm still needs to be confirmed.

Intracanal medicaments were found to have a limited action against bacterial biofilm. The principle of a treatment to reach favorable outcomes in endodontic infection management requires the recognition of the problem and the removal of the etiological factors.

Longitudinal studies signalize that there is yet no accurate solution to eliminate or disrupt the root canal bacterial biofilm. Other aspects that must be critically observed and judiciously analyzed are the biofilm model to test the antimicrobial endodontic medicaments, the biological indicator, and the time necessary for biofilm formation.


George S, Kishen A. In vivo studies, in humans Related to the root canal biofilm Randomized controlled trials RCT Related to the efficacy of intracanal medicaments on biofilm English-language articles. Most studies about endodontic biofilm are in vitro experiments.

Relevant aspects of the studies that met the inclusion criteria were considered, such as the experimental model and sample size, the time lapsed from the initial endodontic treatment until the present moment, the method of identification of the bacteria, the presence of bacteria on the initial samples, the chemical substances used during the root canal disinfection, the time of maintenance of the intracanal dressing prior to obturation, and the efficacy of the medicaments against the tested bacteria.

Despite all known limitations, studies that are not developed in humans are also relevant because, prior to clearance for human use, biological evaluations of dental materials, meficaments and secondary tests are required In vitro infection and disinfection of dentinal tubules.

There was a problem providing the content you requested

In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine against selected single-species biofilms. Chavez de Paz, et al.

Identification and localization of extraradicular biofilm-forming bacteria associated with refractory endodontic pathogens. The microenvironment of root canal presents excellent medjcaments to establish microbial growth Therefore, care should be taken to avoid inappropriate extrapolation of results, which does not allow a clinical decision for therapeutic protocols in humans.

The efficacy of a particular agent was dependent on the nature of the organism in the biofilm and on the contact time. Bacterial biofilm has an open architecture with channels traversing from the biofilm surface.

Can Med Assoc J. YAG laser irradiation on some endodontic pathogens ex vivo.

The results of the analysis demonstrated inefficacy of intracanal medicaments on bacterial biofilm. The penetration of microorganisms in infected root dentin have shown variations considering the experimental model, the biological indicator and the time of incubation employed in the studies Table 4. Evidence-based dentistry involving systematic reviews or meta-analyses has been the ultimate goal to integrate the best available research evidence with clinical experience.


EM evaluation of bacterial biofilm and microorganisms on the apical external root surface of human teeth. Plaque as a biofilm: For the electronic search strategy the terms presented in Table 1 were used as keywords in several combinations.

Several studies have been developed with different bacterial biofilm models to test the antimicrobial effectiveness of endodontic medicaments 19 – 111619242635 Response to alkaline stress by root canal bacteria in biofilms.

Biofilm, Intracanal medicaments, Antimicrobial efficacy. For all reasons addressed in this paper, and considering the heterogeneity of guidelines to study antimicrobial strategies for endodontic infections and the high clinical success estimate, adequate disinfection assisted by the intracanal medicaments reduces the bacterial population and favors the prognosis. Inclusion criteria In vivo studies, in humans. Bactericidal effect of Nd: Microbiological monitoring and results of treatment of extraradicular endodontic infection.

Surface adherence by bacteria to form biofilms is a good example medlcaments bacterial adaptation. The major difficulty found in the present study was the great deal of available information, and the large number of investigations with agreeing intracabal disagreeing conclusions.

Comparative evaluation of antimicrobial efficacy of sodium hypochlorite, MTAD, and Tetraclean against Enterococcus faecalis biofilm. Please review our privacy policy.


However, innumerous published articles on endodontic infection control are motive of controversy 19 – medicamennts1619242635 The invasion of root dentinal tubules by root intraccanal bacteria is a multifactorial event in which a limited number of oral bacterial species have the required properties to participate Reduction ihtracanal endodontic microbiota has been achieved by a series of antimicrobial strategies that include root canal preparation, irrigating solutions, intracanal dressing, and root canal filling.

Abstract The purpose of this paper is to discuss critically the antibacterial efficacy of intracanal medicaments on bacterial biofilm. This fact limited the performance of a meta-analysis. Susceptibility of oral bacterial biofilms to antimicrobial Agents. Duggan and Sedgley 10 tested the hypothesis that the ability of E. An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis.